Research & Evidence

Our Clinically-Informed Foundation

LEAN4™ is built on decades of peer-reviewed research and authoritative health guidelines. Every element of our 4-pillar framework — Learn, Exercise, Adapt, Nutrition — is rooted in proven methods shown to improve fat loss, metabolic health, and longevity.

This page provides direct access to the research and guidelines that underpin our program.

Full Research Reference Document

The LEAN4™ Evidence Compendium consolidates the peer-reviewed studies and guideline sources that form the backbone of our system. It is intended for members, partners, healthcare professionals, and anyone seeking to review the scientific foundation of LEAN4.

Download the Evidence Compendium

Peer-Reviewed Journals:

  • The New England Journal of Medicine

  • JAMA (Journal of the American Medical Association)

  • The Lancet

  • British Journal of Sports Medicine

  • Obesity Reviews

  • Circulation

  • Cell Metabolism

  • American Journal of Clinical Nutrition

From Research to Real-World Application

While the research provides the foundation, results come from applying these findings in a structured, sustainable way. LEAN4™ transforms this evidence into an actionable program designed for real-life results.

See How LEAN4 Works

Last Reviewed

Last updated: July 2025 — This page is reviewed regularly to ensure all references remain current with the latest available research.